The Avera Research Institute has been awarded $58 million in grant dollars to be distributed over a seven-year period.
The health care network says these dollars will go towards research to benefit the health of mothers and children in Native and rural communities.
Both grants come from the National Institutes of Health.
The first, totaling up to $47 million, is part of the Environmental Influences on Child Health Outcomes research network.
The second $11 million grant aims to reduce pregnancy-related inequities and will create the Maternal American Indian Rural Community Health Research Center.